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Buspirone has an affinity for brain D2dopamine receptors, where it buspirone acts as an antagonist and agonist, and for the 5-HT1A receptors, where it acts as an agonist .
Buspirone does not block the neuronal reuptake of monoamines buspirone is not blocked by buspirone and, on chronic administration, it does not lead to changes in receptor density in the models investigated .
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